P2Y purinoceptor subtypes recruit different Mek activators in astrocytes
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چکیده
منابع مشابه
Signaling and Ca Wave Propagation in Dorsal Spinal Cord Astrocytes
ATP is known to act as an extracellular messenger mediating the propagation of Ca waves in astrocyte networks. ATP mediates Ca waves by activating P2Y purinoceptors, which mobilize intracellular Ca in astrocytes. A number of P2Y purinoceptor subtypes have been discovered, but it is not known which P2Y subtypes participate in transmitting astrocyte Ca waves. Here, we show that ATP analogs that a...
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ATP, UTP, and their corresponding disphosphates function as intercellular signaling molecules when released to, or generated within, extracellular compartments. Genes encoding eight G protein-coupled P2Y nucleotide receptor subtypes (von Kugelgen and Wetter, 2000), seven ionotropic P2X nucleotide receptor subtypes (North, 2002), and at least nine different ecto-nucleotidases (Zimmermann, 2000) ...
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The expression of the nucleotide receptors P2X1, P2X2, P2X7, P2Y1, P2Y2 and P2Y4, in the pancreas of the streptozotocin-induced diabetic rat was investigated using immunohistochemistry. In diabetic animals, P2X7 receptor expression, normally located in the outer periphery of the islet, was increased and located inside the islet. Double-labelling experiments, using antibodies raised against insu...
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Physiological and pharmacological studies have demonstrated that extracellular ATP, acting through P2Y(2) purinoceptor, modulates water permeability of renal medullary collecting duct cells and the secretion of ions, mucin, and surfactant phospholipids by respiratory epithelia. Here we provide direct molecular evidence for the expression of P2Y(2) purinoceptor in these cells. RT-PCR confirmed P...
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Microparticles are shed from the platelet membrane upon platelet activation by strong agonists, and they aid in clot formation. As the P2Y1 and the P2Y12 receptors differentially contribute to different platelet functions, we studied the relative contribution of the P2Y1 and P2Y12 receptors to microparticle formation from platelets. The P2Y12 receptor antagonist AR-C 69931MX, but not the P2Y1 r...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2000
ISSN: 0007-1188
DOI: 10.1038/sj.bjp.0703138